They are the ideal tools for companies who lack the financial resources and / or the staff required for generating spreadsheet solutions with specific programs. At present, the most requested types of ready-made spreadsheet solutions are "Spreadsheets for Small Business" and the subcategory "Spreadsheets for Actors".
Size limitation : When a spreadsheet is first constructed and tested, the size tends to be small. However, as the spreadsheet grows with more and more data, it start slowing down, until it reaches that point where your feet go to sleep while you waiting for the re-calculation to finish.
Not dynamic : Data ranges become redundant when new records are added, resulting in established formulae needing to be altered. Overlooking these errors can be embarrassing and downright expensive, especially if important decisions are being made based on the data.
You could make money doing something you love (or like [or maybe not so much but just really good at]). It's great to see a spreadsheet come together, and usually a lot better than what you originally envisioned. Especially when the dang thing works.